Force transmission balance through adhesions determines multicellular handedness
Ishibashi, T.†, Nishizawa, R., Ogita, G., Tokushige, N., Shibata, T.† (2026) bioRxiv.
CV
Education
- Ph.D., Department of Biological Sciences, Osaka University, Mar 25, 2019
- MS, Department of Biological Sciences, Osaka University, Mar 28, 2016
- BS, Department of Biological Sciences, Osaka University, Mar 25, 2014
Research Experiences
- 2026 - Today: Research Scientist
- Laboratory for Physical Biology, BDR, RIKEN, Japan
- Supervisor: Prof. Tatsuo Shibata
- 2023 - 2026: Special Postdoctoral Researcher
- Laboratory for Physical Biology, BDR, RIKEN, Japan
- Supervisor: Prof. Tatsuo Shibata
- 2022 - 2023: Postdoctoral Fellow (PD), Research Fellowship for Young Scientists, JSPS
- Also as a Visiting Scientist
- Laboratory for Physical Biology, BDR, RIKEN, Japan
- Supervisor: Prof. Tatsuo Shibata
- 2021 - 2022: Research Scientist
- Laboratory for Physical Biology, BDR, RIKEN, Japan
- Supervisor: Prof. Tatsuo Shibata
- 2019 - 2021: Program-Specific Researcher
- Laboratory of Insect Ecology, Graduate School of Agriculture, Kyoto University, Japan
- Supervisor: Prof. Kenji Matsuura
- 2016 - 2019: Research Fellowship for Young Scientists (DC1), JSPS
- Laboratory of Cell Biology, Department of Biological Sciences, Osaka University, Japan
- Supervisor: Prof. Kenji Matsuno
- 2011 - 2012: Lab technician
- Laboratory of Genome and Chromosome Functions, Institute for Protein Research, Osaka University, Japan
- Supervisor: Prof. Akira Shinohara
Publications
Total: 16, Peer-reviewed: 14
Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton
Yamamoto, T.*, Ishibashi, T.*, Kiyosue-Mimori, Y., Hiver, S., Tokushige, N., Tarama, M., Takeichi, M., Shibata, T.† (2025) eLife, 14:e102296. ◎
Transgenerational epigenetic effect of kings’ aging on offspring’s caste fate mediated by sperm DNA methylation in termites
Takata, M.*, Takahashi, M.*, Ishibashi, T., Tasaki, E., Rueppell, O., Vargo, L. E., Matsuura, K.† (2025) Proceedings of the National Academy of Sciences, 122 (24). ◎
Optical microscopic imaging, manipulation, and analysis methods for morphogenesis research
Katoh, A. T.*†, Fukai, T. Y.*†, Ishibashi, T.*†. (2024) Microscopy, 73 (3):226-242. ◎
Antiviral effects of micafungin against pteropine orthoreovirus, an emerging zoonotic virus carried by bats
Hondo, E.*†, Katta, T.*, Sato, A., Kadofusa, N., Ishibashi, T., Shimoda, H., Katoh, H., Iida, A. (2024) Virus Research, 339:199248. ◎
Plastic brain structure changes associated with the division of labor and aging in termites
Ishibashi, T.*, Waliullah, A.S.M.*, Aramaki, S., Kamiya, M., Kahyo, T., Nakamura, K., Tasaki, E., Takata, M., Setou, M., Matsuura, K.† (2023) Development, Growth & Differentiation, 65 (7):374-383. ◎
The Drosophila AWP1 ortholog Doctor No regulates JAK/STAT signaling for left-right asymmetry in the gut by promoting receptor endocytosis
Lai, YT., Sasamura, T., Kuroda, J., Maeda, R., Nakamura, M., Hatori, R., Ishibashi, T., Taniguchi, K., Ooike, M., Taguchi, T., Nakazawa, N., Hozumi, S., Okumura, T., Aigaki, T., Inaki, M.†, Matsuno, K.† (2023) Development, 150 (6). ◎
extra macrochaetae, encoding Drosophila Id, controls apical cell shape in the hindgut epithelium
Ishibashi, T., Matsuno, K.† (2022) microPublication Biology. ◎
Statistical validation verifies that enantiomorphic states of cell chirality are determinant dictating the left- or right-handed direction of the hindgut rotation in Drosophila
Ishibashi, T., Inaki, M., Matsuno, K.† (2020) Symmetry, 12(12):1991. ◎
A non-invasive method for sexing first and second instar larvae of termites using external morphology
Takata, M.†, Inagaki, T, Ishibashi, T., Tasaki, E, Matsuura, K. (2020) Insectes Sociaux, 67 (4):487–493. ◎
E and Id transcription factors regulate cell chirality to induce left-right asymmetric morphogenesis of gut in Drosophila
Ishibashi, T., Matsuno, K.† (2020) Annual Report of Research Center for Structural Thermodynamics, 40:82-83.
ATeam technology for detecting early signs of viral cytopathic effect
Doysabas, KCC., Oba, M., Ishibashi, T., Shibata, H., Takemae, H, Shimoda, H., Mizutani, T., Iida, A., Hondo, E.† (2020) Journal of Veterinary Medical Science, 82(3):387-393. ◎
Cells with Broken Left–Right Symmetry: Roles of Intrinsic Cell Chirality in Left–Right Asymmetric Epithelial Morphogenesis
Utsunomiya, S., Sakamura, S., Sasamura, T., Ishibashi, T., Maeda, C., Inaki, M.†, Matsuno, K.† (2019) Symmetry, 11:4. ◎
E and ID proteins regulate cell chirality and left–right asymmetric development in Drosophila
Ishibashi, T., Hatori, R., Maeda, R., Nakamura, M., Taguchi, T., Matsuyama, Y., Matsuno, K.† (2019) Genes to Cells, 24:214. ◎
Chiral cell sliding drives left-right asymmetric organ twisting
Inaki, M., Hatori, R., Nakazawa, N., Okumura, T., Ishibashi, T., Kikuta, J., Ishii, M., Matsuno, K.†, Honda, H.† (2018) eLife, 7:e32506. ◎
A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster
Nakayama, M., Ishibashi, T., Ishikawa, HO., Sato, H., Usui, T., Okuda, T., Yashiro, H., Ishikawa, H., Taikou, Y., Minami, A., Kato, K., Taki, M., Aigaki, T., Gunji, W., Ohtsu, M., Murakami, Y., Tanuma, S., Tsuboi, A., Adachi, M., Kuroda, J., Sasamura, T., Yamakawa, T., Matsuno, K.† (2014) BMC Genetics, 15:46. ◎
- ◎ signs indicate peer reviewed papers.
- * signs indicate equally contributed authors.
- † signs indicate corresponding authors.
Awards
Total: 11
FEBS Best Short Talk Award 2026
FEBS Workshop 2026 "Biochirality across scales"
RIKEN Ohbu Award 2025
RIKEN
Poster Presentation Award
Team meeting of Transformative Research Areas (A): Mechanical Self-transformation of Living Systems
DGD Young Investigator Paper Award
The 75th Annual Meeting of the Japanese Society of Developmental Biologists
MBSJ2023 Best Science Pitch Award
The 46th Annual Meeting of the Molecular Biology Society of Japan
Young Scientist Award for Presentation
The 75th Annual Meeting of the Japanese Society for Cell Biology
Outstanding Poster Presentation Award
The 3rd Area Conference of the Transformative Research Areas (A): Mechanical Self-transformation of Living Systems
First Place for Outstanding Presentation
2017 National Tsing-Hua University - Osaka University Life Science Student Symposium
Excellent Award
2016 National Tsing-Hua University - Osaka University Life Science Student Symposium
Best Popularity Award
2016 National Tsing-Hua University - Osaka University Life Science Student Symposium
Best Presentation Award
The 5th Annual Meeting for Whole-Organism Science Society
Funding
Total: 7
Elucidation of adhesive molecule functions that links cellular and multicellular left-right asymmetries
ACT-X, Japan Science and Technology Agency
Elucidation of the mechanism by which actomyosin emerges cell chirality
Grant-in-Aid for Early-Career Scientists
Yazaki Travel Fellowship
Yazaki Memorial Foundation for Science and Technology
DGD Fellowship
Japanese Society of Developmental Biologists
Elucidation of the mechanism by which cell chirality emerges left-right asymmetric morphogenesis at the multicellular level
Grant-in-Aid for JSPS Fellows
A study of mechanical force as an element of the signaling cascade controlling embryonic development
Grant-in-Aid for JSPS Fellows
Presentations
Total: 35
Force transmission balance through adhesions determines multicellular handedness
Oral Presentation at FEBS Workshop 2026 "Biochirality across scales", Theater Grand Chateau Valrose, Nice, France
Adhesion mechanics that convert cell chirality into multicellular left-right asymmetry
Oral Presentation at The Joint Meeting of JSCB 77th and JSDB 58th, WINC Aichi, Nagoya, Aichi, Japan
Cell-Cell and Cell-Substrate Adhesion Balance Translates Cell Chirality Into Multicellular Left-Right Asymmetry
Oral and Poster Presentation at Gordon Research Conference "Cell-Cell Junctions: Integrating Cell Signals and Mechanical Force in Development and Disease", Les Diablerets Conference Center, Les Diablerets, Switzerland
Cellular-level left-right asymmetry, cell chirality, induces the chiral collective rotation of multicellular colony
Oral Presentation at The 47th Annual Meeting of the Molecular Biology Society of Japan, Fukuoka International Congress Center, Fukuoka, Japan
Cellular-level left-right asymmetry, cell chirality, induces the chiral collective rotation of multicellular colony
Oral Presentation at The 76th Annual Meeting of the Japan Society for Cell Biology, Tsukuba International Congress Center, Tsukuba, Japan
Cellular-level left-right asymmetry, cell chirality, induces the chiral collective rotation of multicellular colony
Invited Talk at IUPAB 2024, Kyoto International Conference Center, Kyoto, Japan
Cellular-level left-right asymmetry, cell chirality, induces the chiral collective rotation of multicellular colony
Oral Presentation at The 57th Annual Meeting of the Japanese Society of Developmental Biologists, Miyako Messe, Kyoto, Japan
Cell chirality induces collective rotation via the left-right asymmetric formation of lamellipodia and focal adhesions
Oral Presentation at The 46th Annual Meeting of the Molecular Biology Society of Japan, Kobe Port Island, Kobe, Japan
Cell chirality emerges left-right asymmetry at the multi-cellular level: left-right asymmetric formation of lamellipodia and focal adhesions drive collective migration
Oral Presentation at The 56th Annual Meeting of the Japan Society of Developmental Biologists, Sendai International Center, Miyagi, Japan
細胞キラリティは葉状仮足と焦点接着斑の左右非対称な形成を介して細胞集団のキラルな回転運動を生み出す
Oral Presentation at The 75th Annual Meeting of the Japan Society for Cell Biology, Nara Prefectural Convention Center, Nara, Japan
Cell chirality emerges left-right asymmetry at the multi-cellular level: left-right asymmetric formation of lamellipodia and focal adhesions drive collective migration
Poster Presentation at The 3rd Area Conference of the Transformative Research Areas (A): Mechanical Self-transformation of Living Systems, Kanazawa Bunka Hall, Ishikawa, Japan
生命はいかにして「左右」を定義するのか? 分子から多細胞まで階層横断的にキラリティが生まれる仕組み
Oral Presentation at GTR Seminar, Nagoya University, Aichi, Japan
Cell chirality induces collective rotation via the left-right asymmetric formation of lamellipodia and focal adhesions
Oral Presentation at Yamada Conference LXXV: Origin of left-right asymmetry in animals, RIKEN BDR, Hyogo, Japan
Cell chirality emerges left-right asymmetry at the multi-cellular level: left-right asymmetric formation of lamellipodia and focal adhesions drive collective migration
Poster Presentation at The 45th Annual Meeting of the Molecular Biology Society of Japan, Makuhari Messe, Chiba, Japan
Cell chirality emerges left-right asymmetry at the multi-cellular level: left-right asymmetric formation of lamellipodia and focal adhesions drive collective migration
Oral Presentation at The 45th Annual Meeting of the Molecular Biology Society of Japan, Makuhari Messe, Chiba, Japan
Cell chirality induces directional collective rotation via left-right asymmetric formation of lamellipodia
Oral Presentation at 3rd FRANCO-JAPANESE Developmental Biology meeting, Palais Universitaire Strasbourg, Strasbourg, France
Cell chirality emerges left-right asymmetry at the multi-cellular level: left-right asymmetric formation of lamellipodia and focal adhesions drive collective migration
Oral Presentation at The 74th Annual Meeting for the Japanese Society for Cell Biology, Tower Hall Funabori, Tokyo, Japan
Cell chirality emerges left-right asymmetry at the multi-cellular level: left-right asymmetric formation of lamellipodia and focal adhesions drive collective migration
Oral Presentation at 55th Annual Meeting for the Japanese Society of Developmental Biologists, Kanazawa Bunka Hall, Ishikawa, Japan
Cell chirality emerges left-right asymmetry at the multi-cellular level: left-right asymmetric formation of lamellipodia and focal adhesions drive collective migration
Poster Presentation at 55th Annual Meeting for the Japanese Society of Developmental Biologists, Kanazawa Bunka Hall, Ishikawa, Japan
Cell Chirality Emerges Collective Cellular Rotation by Regulating Left-Right Asymmetric Formation of Lamellipodia
Poster Presentation (Online) at RIKEN BDR Symposium 2022 "Emergence in Biological Systems: Challenges to Bridging Hierarchies", RIKEN BDR, Hyogo, Japan
Cell Chirality Emerges Collective Cell Rotation
Oral Presentation (Online) at Current Topics in Bioscience, Osaka University, Osaka, Japan
Plastic change of brain structure underlying division of labor in termites
Poster Presentation at XXVI International Congress of Entomology, Finlandia Hall, Helsinki, Finland
Morphogenesis in Drosophila; How organisms develop their shapes
Invited talk at Kakuchi-seminar, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
E and Id regulates left-right asymmetric development during embryonic development of Drosophila
Poster Presentation at 13th Japanese Drosophila Research Conference, Med-Pharm Collaboration Building, Kyoto, Japan
E and Id regulates left-right asymmetric development during embryonic development of Drosophila
Oral Presentation at Joint Annual Meeting of 51st JSDB and 70th JSCB, Tower Hall Funabori, Tokyo, Japan
E and Id regulates left-right asymmetric development during embryonic development of Drosophila
Oral Presentation at 2017 National Tsing-Hua University - Osaka University Life Science Student Symposium, Nambu-Hall, Osaka, Japan
E and Id regulates left-right asymmetric development during embryonic development of Drosophila
Poster Presentation at 4th Asia Pacific Drosophila Research Conference, Convention Center, Osaka, Japan
Transcriptome analysis to identify genes responding to mechanical force in developing Drosophila embryos
Oral Presentation at 2016 National Tsing-Hua University - Osaka University Life Science Student Symposium, National Tsing Hua University
Transcriptome analysis to identify genes responding to mechanical force in developing Drosophila embryos
Poster Presentation at The 57th Annual Drosophila Research Conference, Orlando World Center Marriott
Transcriptome analysis to identify genes responding to mechanical force in developing Drosophila embryos
Poster Presentation at The 5th Annual Meeting for Whole-Organism Science Society, Sigma Hall, Osaka, Japan
Transcriptome analysis to identify genes responding to mechanical force in developing Drosophila embryos
Oral Presentation at The 5th Annual Meeting for Whole-Organism Science Society, Sigma Hall, Osaka, Japan
Transcriptome analysis to identify genes responding to mechanical force in developing Drosophila embryos
Poster Presentation at 3rd Asia-Pacific Drosophila Research Conference, 北京会議中心
Transcriptome analysis to identify genes responding to mechanical force in developing Drosophila embryos
Poster Presentation at MBI-Japan Joint Symposium, National University of Singapore, Singapore
Transcriptome analysis to identify genes responding to mechanical force in developing Drosophila embryos
Oral Presentation at Summer Workshop for Young Scientists, Japanese Society of Developmental Biologists, Asamushi, Aomori, Japan
Transcriptome analysis to identify genes responding to mechanical force in developing Drosophila embryos
Poster Presentation at The 66th Annual Meeting of the Japan Society for Cell Biology, Shin-Kokaido, Nara, Japan
Teaching
Total: 33
Invited Lecture: “Cell Chirality Emerges Collective Cell Rotation”
Current Topics in Bioscience at Zoom, Osaka University, Osaka University
共通教育実習 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
Teaching assistant for Student Exercise
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
Teaching assistant for Student Experiment
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
共通教育実習 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
共通教育実習 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
生物学実習2 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
生物学実習2 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
生物学実習2 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
生物学実験2 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
Teaching assistant for Student Exercise
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
Teaching assistant for Student Experiment
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
生物学実験2 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
生物学実験2 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
生物学実験2 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
生物学実験2 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
G30 Basic Biology Experiments (TA)
Student Experiment for Foreign Students at International College, Osaka University, International College, Osaka University
G30 Basic Biology Experiments (TA)
Student Experiment for Foreign Students at International College, Osaka University, International College, Osaka University
共通教育実習 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
共通教育実習 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
Teaching assistant for Student Exercise
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
Teaching assistant for Student Experiment
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
生物学入門 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
共通教育実習 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
共通教育実習 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
G30 Basic Biology Experiments (TA)
Student Experiment for Foreign Students at International College, Osaka University, International College, Osaka University
G30 Basic Biology Experiments (TA)
Student Experiment for Foreign Students at International College, Osaka University, International College, Osaka University
Teaching assistant for Student Exercise
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
Teaching assistant for Student Experiment
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
共通教育実習 (TA)
Student Experiment for Undergraduate Students at Center for Education in Liberal Arts and Sciences, Osaka University, Center for Education in Liberal Arts and Sciences, Osaka University
Teaching assistant for Student Experiment
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
Teaching assistant for Student Experiment
Student Experiment for Undergraduate Students of Dept. of Biol. Sci. at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
Teaching assistant for Icho-sai
School Festival at Department of Biological Sciences, Osaka University, Department of Biological Sciences, Osaka University
Skills
- Skills in cultured cells & D. melanogaster
- Developmental biology
- Genetics
- Cell biology
- Molecular biology
- Imaging analysis
- Bioinformatics
- RNA-seq
- Whole genome sequencing
- ChIP-seq
- Ecological research in termite, R. speratus
- Behavioural analysis
- Field work